MitoPrime®(L-Ergothioneine), known as the new “longevity vitamin”, is often considered the most complete oral antioxidant known, which exhibits profound anti-inflammatory actions and protects DNA and mtDNA.

NNB Nutrition (https://nnbnutrition.com/), a leading branded ingredient supplier and creator, delivers new and innovative ingredients with an elite global team of scientists, recently announced that it has filed a PCT patent ( PCT/CN2021/ 101541) on the use of MitoPrime® (L-Ergothioneine) to relieve and prevent age-related macular degeneration (AMD). In pursuing this patent, NNB discovered that MitoPrime can actively prevent age-associated visual degeneration in mammals.

Age-related macular degeneration consists of a phenomenon including eyestrain, blurred vision, dry eyes, eyestrain and eventually even blindness, etc. more than 25% of people over 75. In the United States alone, 2 million people have advanced AMD and more than 8 million people have an intermediate form of this age-related degeneration. These figures are expected to increase by 50% in 2022. In Saudi Arabia, AMD accounts for 3.3% of the leading causes of blindness in people over 50. As human society ages globally, especially beyond the age of 40, senescence and degeneration of ocular organ function become more common, which could lead to inconveniences for individuals and increase the social burden. Elderly people with senescence and degeneration of eye organ function can be called age-related visual degeneration. Age-related visual degeneration can damage the outer retina, such as the retinal pigment epithelium (RPE, an important role in light absorption), Bruch’s membrane (BM), and the underlying choroid (choriocapillaris ) and photoreceptors.[1]. Therefore, focusing on the eye health of the elderly is becoming a new trend in today’s healthcare product market.

For this reason, NNB found that MitoPrime surely added more market value. Not only that, but NNB’s patent experiment was also carefully designed: NNB used zebrafish as an experimental object in the patent experiment, and the main reason is that the fundus model of zebrafish is recognized in academic circles as the most similar model to the human eye. . Meanwhile, zebrafish visual fatigue is also very similar to that of humans[2]. Therefore, as long as the efficacy of the substance in the eyes of zebrafish is proven, it can be concluded that it will have the same efficacy in the human body. NNB is also the first company to use zebrafish to study the effect of EGT on eye health, which is also an innovative experiment of great importance in the dietary supplement industry.

In the nnb experimental report, researchers used inducing factors to cause zebrafish to first show symptoms of age-related macular degeneration, then these zebrafish were pooled and placed in water containing different substances. Researchers found that zebrafish placed in water containing MitoPrime had a significant reduction in the degree of macular degeneration, as well as improved eye health; the effect was even comparable to that of zebrafish placed in a liquid medicine specially designed to relieve macular degeneration.

This research published by NNB perfectly confirmed the role of MitoPrime (Ergothioneine) in the relief of age-related macular degeneration. Therefore, this patent filed by NNB claimed that L-ergothioneine can be used as an active ingredient to alleviate and prevent age-related visual degeneration in aged mammals. It can be said that this patented experiment has greatly expanded the use of MitoPrime. For brand owners who plan to develop eye health product lines, MitoPrime fits their needs perfectly.

Afight MitoPrime®

MitoPrime®, NNB’s pure ergothioneine, is NNB Biotech’s bio-perfected form of the histone derivative L-ergothioneine which is now supported by over 15 studies including clinical trials, human cells and pharmaceutical model C Elegans. MitoPrime® L-ergothioneine is a naturally water-soluble amino acid with a powerful energizing antioxidant property, which benefits longevity, antioxidant, DNA and genome stability, boosting immunity , anti-inflammatory, and cellular and organ health, and can be formulated or function as the sole active ingredient. It is 100% natural, non-GMO and contains no additives of any kind.

NNB believes that regulatory certification such as GRAS and FSSAI, as well as clinical trials and patents can add more value to the product itself, and also allow MitoPrime to be used more widely, such as in daily supplements, skin care, cosmetics, food, beverages, etc. NNB also looks forward to discussing broader application scenarios of MitoPrime with you.

Claims of MitoPrime®

Can be used as an active ingredient to alleviate and prevent age-related visual degeneration in old mammals (mammals include humans)

MitoPrime® can be prepared as a nutritional or drinkable or pabular or pharmaceutical composition as such and used in the food, beverage, nutritional or pharmaceutical field –

– Attenuation of skin aging, improvement of radiance and luminosity

– The antioxidant capacity is 10 times greater than that of polyphenols in fruits and vegetables

– Shown 34 times more effective than glutathione

– Long half-life of antioxidant compounds, 32 days (glutathione half-life is 8 minutes)

– Removes DNA damaging acids

About NNB

NNB is the leading ingredient-focused biotechnology company employing over 100 research scientists from over 10 countries who research, design and supply unique ingredients to this industry to maximize health, increase performance, increase longevity and improve health. ‘appearance. NNB promotes partnerships with companies in the fields of nutraceuticals, pharmaceuticals and medical research.

References:

1. Zhao, Z., et al., Age-related retinopathy in NRF2-deficient mice. PLoS ONE, 2011. 6(4): p. e19456-e19456.

2. Kajimura, Shingo, Aida et al. Understanding Hypoxia-induced Gene Expression in Early Development: In Vitro and In Vivo Analysis of Hypoxia-Inducible Factor 1-regulated Insulin-regulated Zebrafish Growth Factor 1 Gene Expression.[J]. Molecular and Cellular Biology, 2006.

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